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Invincible

Defy Your Genetic Destiny to Live Better, Longer

Coming Soon

Contributors

By Florence Comite, MD

Formats and Prices

On Sale
Apr 28, 2026
Page Count
304 pages
Publisher
Little Brown Spark
ISBN-13
9780316595568

Price

$14.99

Price

$19.99 CAD

Discover a proven path to optimal health for the rest of your long life with this groundbreaking book revealing how you can harness the power of precision medicine to live healthier longer.

Your genes do not have to be your destiny. Groundbreaking endocrinologist and longevity expert Florence Comite, MD has helped thousands of patients reverse biological aging and halt emerging diseases. Her proactive precision care is built on one central truth: your unique biology is the key to your longevity. Drawing on two plus decades of clinical research, she shares her Nof1 approach—tailored to your unique needs and backed by science—to help you reclaim your health, extend your active years, and enjoy the vibrant life you deserve—at any age.
 
Invincible gives you the tools to:
  • Decode your body’s Five Key Biomarkers—a personalized snapshot of your current and future health
  • Identify your risks hidden in your genes, family history, and daily habits
  • Discover which of the Seven Patterns of Health Decline you may be following—and how to break free
  • Take targeted, practical steps to reverse biological aging, prevent metabolic decline, and thrive in mind and body for decades to come
Adding candles to your birthday cake is inevitable. Aging well makes you invincible.

  • "Invincible is a powerful, science-driven roadmap to healthy longevity. Dr. Florence Comite brings clarity, authority, and urgency to a conversation every patient is ready to have about extending not just lifespan, but healthspan. This book empowers readers to understand their biology, take action earlier, and age with strength, resilience, and intention.” 
    Mary Claire Haver, MD, author of The New Menopause
  • Invincible is a powerful roadmap for extending healthspan and reversing the root causes of aging. Dr. Florence Comite brings together cutting-edge science, precision medicine, and real-world clinical wisdom to show that decline is not inevitable. This book gives you the tools to understand your unique biology—and change the trajectory of your health for decades to come."
    Mark Hyman, author of Young Forever
  • "I've known Dr. Florence Comite for over 30 years. She is a brilliant, forward-thinking physician-scientist, and her book will guide anyone who wants to expand their healthspan to match their lifespan." 
    Dean Ornish, MD, clinical professor of medicine at UCSF and author of UnDo It!
  • "In her groundbreaking book, Invincible, Dr. Florence Comite reveals a practical and personalized longevity paradigm far beyond what conventional medicine has to offer. Using targeted interventions and protocols that address the most common aging concerns, Dr, Comite proves your DNA is not your destiny and your biology is not your biography. At last, extending one's "youthspan" and reversing the aging  process is at hand and I can't wait to start implementing many of Dr. Comite's strategies myself."
    Ann Louise Gittleman, PhD, CNS, author of Radical Longevity
  • "Dr. Comite has been a visionary leader in Precision Medicine for decades. With Invincible, she provides a roadmap for reversing aging and building strong, resilient, health for life. "
    David Zinczenko, author of Eat This, Not That! and CEO of Galvanized Media
  • "As far as I know, only Florence Comite has been truly practicing healthspan medicine for twenty or more years.  
    This book is a masterclass in longevity. There simply isn’t a better one."
    Bracken Darrell, CEO of VF Corporation
  • “Through clear, science-backed strategies and a deep dive into biomarkers, this book equips readers with the tools to halt biological aging, prevent disease before it takes hold, and optimize health at every stage of life.” 
    Jessica Shepherd, MD, MBA, FACOG, author of Generation M
  • "If, like me, the concept of a 'longevity doctor' brings to mind visions of Silicon Valley biohacking regimens, then Dr Comite’s new book will be a real eye opener. I was struck by how closely her paradigm for human health mirrors what the very best farmers practice in their fields: they don’t fixate on disease, they study health. They ask questions like 'How do we equip crops to defend themselves?'
    Invincible applies a similarly elegant approach to the human body, offering a framework that feels neither fringe nor trendy but obvious: true health is about cultivating vitality and preventing disease, not just treating it once it appears. A must read." 
    Dan Barber, chef and co-owner of Blue Hill at Stone Barns, and author of The Third Plate

Florence Comite, MD

About the Author

Florence Comite, MD, clinician-scientist, endocrinologist, and global authority on healthy longevity, is founder of the Comite Center for Precision Medicine & Healthy Longevity in New York, Palo Alto, and Miami Beach. A Yale School of Medicine graduate and faculty member for 25 years, Dr. Comite held triple appointments in Endocrinology (Internal Medicine and Pediatrics), and Reproductive Endocrinology (Gynecology and Andrology). As a clinical investigator, she developed research and patented therapies at NIH and Yale. In 1992, she pioneered the nation’s first center for Women’s Health at Yale, redefining integrative care for women. Dr. Comite also founded Groq Health, creating the first physician-led app using her proprietary real-world data offering virtual interventions to help people optimize their health. 

Learn more about this author